- Title
- Biomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera
- Creator
- Ito, Kazuyo; Hoerig, Cameron; Dan, Yee Shan; McFadden, Sally A.; Mamou, Jonathan; Hoang, Quan V.
- Relation
- Communications Engineering Vol. 3, no. 139
- Publisher Link
- http://dx.doi.org/10.1038/s44172-024-00280-7
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2024
- Description
- Retina-derived growth signals relayed from the choroid to the sclera cause remodeling of the extracellular scleral matrix, resulting in myopic ocular elongation. However, to the best of our knowledge, no studies have assessed changes in choroidal stromal biomechanical properties during myopia progression. Here we utilized 7 µm-resolution scanning acoustic microscopy (SAM) to assess biomechanical properties (bulk modulus (K) and mass density (rho)) of choroidal stroma from guinea pig eyes with form-deprivation (FD) induced myopia. The choroidal stroma had considerable intrinsic strength arising from its biomechanical properties and these were differentially affected by myopia in central and peripheral regions. Choroidal stromal biomechanical values were also highly correlated with those in adjacent scleral regions, and the choroidal stromal-scleral association was stronger in myopic eyes. Biomechanical changes observed in the choroidal stroma of myopic eyes were mirrored to those observed in the adjacent sclera. These findings suggest that choroidal stromal remodeling may accompany myopia and open the door to the source of the signals that cause scleral remodeling in myopia.
- Subject
- biomechanical properties; myopia; choroidal stroma; scleral; SDG 17; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1517339
- Identifier
- uon:57076
- Identifier
- ISSN:2731-3395
- Rights
- x
- Language
- eng
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